Growth hormone is a key hormone to promote human growth. If the secretion of this substance in the human body is insufficient, it will greatly affect growth and development. Can that type of growth hormone grow higher? Can adults take growth hormone to grow higher? Don’t worry, today we will talk about how growth hormone can promote growth.
Growth hormone can treat short stature
Recombinant Human Growth Hormone (rhGH) is a medicine for the treatment of short stature. It is used to treat diseases without increasing the normal healthy population. And it is only effective for people who have not closed the epiphyseal line. Adults who have closed the epiphyseal line cannot use it to increase it.
Height is lower than that of people of the same age and the significant shortness caused by growth hormone deficiency, so growth hormone is considered. Medicines have strict rules and regulations for use, and doctors will not prescribe such medicines unless they reach the “standard”. The growth hormone therapy can be used only if the following conditions are met.
- Short stature and slow growth
Height is lower than 2 standard deviations (SD) of the average height of healthy people of the same age, same sex and same race or lags behind the 3rd percentile. The figure below shows the criteria for judging whether boys and girls between the ages of 3 and 16.5 are short.
Slow growth refers to the annual growth of less than 7 cm under the age of 3, the annual height from 3 years to puberty is less than 5 cm, and the puberty is less than 6 cm per year.
- Short stature is caused by growth hormone deficiency
There may be many reasons for short stature. In addition to growth hormone deficiency, the pathological conditions include chronic renal insufficiency, idiopathic short stature, less than gestational age children (SGA) without catch-up growth after birth, SHOX gene loss Syndrome, Noonan syndrome, Prader-Willi syndrome, short bowel syndrome, etc. Malnutrition, lack of exercise, and lack of sleep can also cause stunting.
Treatment should be based on symptomatic treatment, and it is determined that growth hormone deficiency can be treated with growth hormone.
If you want to determine the specific development and the reason for the shortness, you need to go to the hospital for the following examinations:
Bone age check, generally use palm, take X-ray film to check the degree of closure of epiphyseal line;
Growth hormone drug challenge test to see if the growth hormone level and secretion are normal;
Thyroid function test to rule out abnormal thyroid function;
Head magnetic resonance imaging to check whether the pituitary gland has contracted or changed.
If the test results are as follows, it is growth hormone deficiency:
Proportionally short, with immature face and normal intelligence development;
After examination, the bone age lags behind the actual age;
Conducted two growth hormone provocation tests, and the peak growth hormone was <10μg / L;
Serum insulin-like growth factor 1 (IGF-1) is lower than normal.
Only after the doctor determines the cause, you can use growth hormone and other treatments for short stature. Do not treat growth hormone as a heightening drug for healthy children, otherwise it may cause negative effects.
Possible side effects of growth hormone.
It is usually safe to use growth hormone therapy as directed by your doctor. But because the growth hormone used for treatment generally needs long-term medication until the epiphyseal line heals, this may last for several years, and the chance of side effects from long-term use of a certain drug will be greatly increased.
The side effects that have been reported include the following.
- Local redness and rash at the injection site
May subside after the injection is stopped, or 3-5 days.
- Water and sodium retention — edema, intracranial hypertension
Retention of water and sodium occurs earlier, which can cause edema of the lower extremities, and can lead to benign intracranial hypertension (pseudocerebral tumor).
Edema usually disappears 7 days after starting treatment. Benign intracranial hypertension can cause headache, vomiting, loss of vision, and optic nerve papillary edema, most of which occur within the first few months of treatment, and some appear later after 3 years of treatment. Symptoms will soon disappear after treatment is stopped. After a period of time, the low-dose treatment can be restarted, and the child can tolerate it.
- Produce growth hormone (GH) antibody
After producing antibodies, it will react with growth hormone and affect the treatment effect, but the incidence is low.
- Affect thyroid function — may cause hypothyroidism
Growth hormone affects pituitary-thyroid function is more common, will make the hidden central thyroid hormone deficiency become obvious, and some may have hypothyroidism. It usually occurs 2-3 months after the start of treatment and usually recovers after oral administration of thyroxine.
- Influencing sex hormones — producing male breast development
In pre-pubertal and adolescent boys, mammary gland development occurs in about 3.2 of 10,000 children treated.
- Affect the skeletal system-scoliosis, spondylolisthesis
Because growth hormone can promote the growth of long bones, treatment may lead to adverse reactions of the skeletal system, including the worsening of children with scoliosis, femoral epiphyseal detachment (femoral head slippage), joint pain, etc.
- Affects glucose metabolism, decreased insulin sensitivity
Growth hormone may reduce the sensitivity of peripheral tissues to insulin, but it will not significantly affect blood glucose stability, and it can gradually recover after stopping treatment.
In most cases, growth hormone does not increase the incidence of diabetes, but it may make type 2 diabetes, which originally occurred in adulthood, earlier.
To control the side effects of growth hormone, long-term follow-up to the hospital for review, children should monitor height, weight and growth rate every 3 months, bone age assessment is required every year, and the dose is adjusted according to the above situation and IGF-1 level.
Adult growth hormone deficiency should be followed up every 1-2 months during the initial treatment. After entering maintenance treatment, it can be followed up every 6 months.