One, pyridine butyric acid
At present, the main synthetic raw materials are radon,4- Chlorpyrifos, or niobium, butyric sebum or salicylic acid, salicylic acid, pyridine itself is a very effective plant hormone.
1.At normal temperature and normal pressure, the hydroxide of salicylic acid is catalyzed by polymer hydrogenation catalyst: esters are esteminated under reflux conditions with organic super acid, and the molars ratio of salicylic acid to ethanol is1：20—1：80。
2.at 70 under the condition of degree, the oxidation reaction is carried out with polymer oxidation reagent, and the molar ratio of adjacent hydroxycyclic ethyl urethral acid to polymer oxidation reagent is1：1.5—1：2
3.at-5Degrees -10degrees for shrinking reaction, reflux hydrolysis under alkaline conditions, acidification at room temperature, cyclone-ketones2-The molar ratio of ethyl methiotate to aniline is1：1
4.at220—-240a derided reaction between degrees to produce plant growth hormone3- Pyridine.
5.The use of additives are polymer hydrogenation catalyst, ethanol, organic super acid and so on.
Salicylic acid is not only a plant hormone, but also an intermediate of other important compounds.
Synthesis Method One:
1.The phenol was mixed into sodium phenol salt sodium phenol in a solution of sodium hydroxide, and the intermediate reactor solid sodium phenol (reactor) was dried by a secondary vacuum
2.In the autoclave, sodium phenol and carbon dioxide are used as reactants to generate sodium salicylic acid and acidized salicylic acid by supercritical reaction.
3.Further refined to obtain purity of99.5%至100%Salicylic acid products.
Synthesis Method 2:
1.The phenol is added to the solution of sodium sulfate, and then reacts with calcium hydroxide, and produces calcium phenolic or calcium sulfate, and finally obtains the solution of sodium phenol and calcium sulfate.
2.After the obtained filtrate, sodium phenol, is dehydrated, it is passed into carbon dioxide and the sodium salicylic acid is produced.
3.Sodium salicylic acid will be obtained in response to sulfuric acid, and salicylic acid and sodium sulfate will be obtained.
4.The resulting sodium sulfate solution is used in the first step of the reaction.
New plant growth regulator trifluoroquinabuteric acid and its derivatives
Synthesis of new plant growth regulators 4,4-3-3-(3-pyridine) butyric acid (TFIBA). With radon and trifluoroethion as the starting raw material, it is based on Fu’s illytic. The Rifmasky reaction (or direct lycinatium with pyridine and trifluoroacetylacetate as the starting raw material) produced 3-hydroxy-4,4,4-trifluoro-3-3-3-dehydroxyene, catalytic hydrogenation and hydrolysis and other steps to obtain 4,4,4-trifluoro-3-3-3-3-butyl) butyric acid. Melting point 118 to 119 degrees C. Involved in high activity, water-soluble 4,4-4-trifluoro-3-The synthesis method of salts of (3-pyridine) and higher-active phenolic sphelis is used as a new plant growth regulator in different crops in agroforestry.
Synthesis Method One:
1.Chloraceacid – sodium chloracetate – benzoic acid (acidization, cooling, filtration, washing, drying) – benzoic acid – chlorinated –Chlorobenzene acetic acid (acetic acid, chloride, ether, sodium carbonate) – coarse2，4-D(Recrystallization) – Boutique2，4-D
2.Synthesis of chloroacetic acid:
a.Add acetic acid and acetic acid equivalent to the reactor10－15%vinegar, warming up and keeping the temperature at80－200degrees into chlorine chlorination.
b.The acetate is chlorinated as an chloride acetate, which emits hydrogen oxide.
c.The resulting hydrogen chloride breaks down acetate into acetic acid and acetyl chloride catalysts.
D.Acetyl chloride is chlorinated as chloracetyl chloride
And.Chloracetyl chloride and acetic acid are acidified, chloraceacid products are obtained and returned to a acetyl chlorine catalyst
Synthesis method 2
First, the phenol is dissolved, and then at the temperature80－110chlorination is carried out to produce dichlorophenol. Chloraceacid and alkali reactions, converted into chloroacetic acid, and then, dichlorophenol reacts with caustic soda to produce sodium dichlorophenol, sodium dichlorophenol and sodium chloroacetate at temperature90－95To perform a condensing reaction between degrees,2.4Sodium salt of chlorobenzeee. then put this sodium salt in thePH值9－10The water phase is purified to reduce the content of its phenols until the required standards are met. After purification, the sodium salt is acidified with hydrochloric acid and converted into2.4Ichlorinebenza. This acid after absorption filtration, so that the chloride content qualified, centrifugal separation drying after becoming a genuine.
a.With a new strains of Kajika mold, namedy-08, its mycelium is white, slightly purple pigment, can produce egg round to long round small sub-spores, the strain in the normal fermentation conditions of the canggu chime mold fermentation to produce erythromycin A4, A7 and A3 products ratio of about 70-80-10-13-7-20 (weight ratio). The strain can be used for large-scale fermentation production of erythromycin A4 and A7, while the undesirable production of erythromycin A3 is very small, making the industrial production of erythromycin A4 and A7 very simple.
b.Chimycin fermentation production of erythromycin A4+7The process, which consists of two parts:
(1) Fermentation process: including temperature culture, calcium carbonate to adjust pH, fermentation process to add compound additives and the use of appropriate medium ingredients.
(2) Extraction process: in erythromycin A4+7The large-hole resin adsorption method is used in the extraction. The organic knot of the twoAfter the joint, not only erythromycin A4+7The yield has been greatly increased, and the extraction saves a lot of energy, while also increasing the extraction rate.
c.The method of extracting erythromycin A4 and A7 from erythromycin fermentation solution was used to extract the chimycin fermentation solution in pH7. 0—6. 8 conditions concentrated 20-30 times, to adjust pH6. 0, so that GA4 precipitation, separated filtout to adjust pH4. 5, so that GA7 precipitation, and then separateout the filtout to adjust pH2. 2, extract GA3 with acetate ethyl lipid. The characteristics of this process are mainly the adoption of segment extraction method. Due to the high concentration multiple of erythromycin fermentation liffraction, when the purity of each extraction process is not sufficient, only the buffer is used to clean the extract of each segment, rather than the use of repeated extraction methods, so that the amount of ethyl acetate is reduced, this method not only reduces costs, but also simplifies the production process.
The method of extracting erythromycin A4 and A7 from erythromycin fermentation solution is characterized by:
1, first of both the erythromycin fermentation solution in pH7. 0-6. 20-30 times concentrated under 8 conditions, to adjust pH6. 0, so that GA4 precipitation, separation of the filtout;
2, the above-mentioned separation of the filth, to adjust pH4. 5, so that GA7 precipitation, again separated the filtout;
3, the above-mentioned re-separation of the filth, to adjust pH2. 2, extract GA3 with acetate ethyl lipid.
Extraction Method 2
a.The solvent extraction process of chimycin fermentation filter is concentrated, and the chimycin fermentation filter is adjusted to pH. 0 to 3. 0, organic phase consisting of organophosphorus (pyridine) and/or amine extractor and sulfonated kerosene thinner (the volume fraction of extractor is 30 to 60%) mixed with water phase liquid for the extraction of erythromycin, control the volume ratio of organic phase to water phase is 1:2 to 5, and then anti-extraction with saturated NaHCO3 solution, The volume ratio between the control of the inverse water phase and the organic phase of the load is 1:3 to 5, and the extraction and anti-extraction operations are carried out at room temperature. The process has a high yield, low energy consumption and no environmental pollution.
b.The solvent extraction process of chimycin fermentation filter is characterized by the transfer of erythromycin fermentation filter to PH. 0 to 3. 0, the organic phase consisting of extractor and sulfonated kerosene thinner (the volume fraction of the extractor is 30 to 60%) mixed with the water phase liquid for the extraction of erythromycin, control the volume ratio of the organic phase to the water phase is 1:2 to 5, and then the anti-extraction with saturated NaHCO3 solution, The volume ratio between the control of the inverse water phase and the organic phase of the load is 1:3 to 5, and the extraction and anti-extraction operations are carried out at room temperature, and the extractagent is said to be an organophosphate (pyridine) in the following structure.
Extraction Method 3
a.A type of erythromycinGA3purification separation method. as a plant growth regulator, erythromycin, whereGA3is an active ingredient, andGA1The existence of theGA3purity,GA3与GA1Is a pair of polar similar substances, the traditional solute extraction method and large hole separation method can not makeGA1与GA3Separation. The invention presents a type of erythromycinGA3Purified separation method to boil50% acetone aqueous solution is a solvent recrystallization, its process is reasonable, easy to operate. The implementation of the present invention can enable erythromycinGA3greatly improved purity.
b.A type of erythromycinGA3A purification separation method characterized by the following steps:
(1)Preparation50% acetone aqueous solution and heated to boiling;
(2)Slowly add erythromycin to the boiling50% acetone aqueous solution, stirred and dissolved until saturated;
(3)Quickly cool to25℃；
(5)Use 50% acetone water solution washing;
Extraction Method 4
A new process for refining erythromycin, especially from solid fermentation mediums, is characterized by the process of the process:
Raw materials (wet song) , granular dry song , multi-level water pumping , filtration , large-hole adsorption of tree esters , de-absorption , concentration , multiple extraction , carbon de-freezing filtration , decompression and concentration , freezing , filtration washing , vacuum drying , finished products .
a.A chimycin (920) synergizer consisting of boric acid and urea, supplemented by potassium nitrate, dihydrophosphate calcium phosphate, magnesium carbonate, and sodium dibase sulfate, is a solid powder mixture. It is mixed with 920, can reduce the amount of 920, thereby reducing the cost of hybrid rice breeding, while maintaining the effect of 920 raw dosage, and has a certain effect of increasing production.
b.A erythromycin synergizer for hybrid rice breeding, which can reduce the amount of erythromycin and maintain its original dosage effect, is characterized by a solid powder mixed with urea and/ or boric acid as the main component, supplemented by potassium nitrate, dihydrophosphate, magnesium carbonate, and sodium sulphal sulfate components.
c.A erythromycin enhancer consists of boric acid, magnesium sulfate, manganese sulfate, zinc sulfate, cobalt sulfate, copper sulfate, sodium sulphate, myosine and other basic components. It is used in conjunction with erythromycin, which enhances the function of erythromycin to promote plant growth and plays a role in regulating the division and differentiation of plant cells. The enhancer is easy to use and inexpensive. The cost of 2 to 10 yuan per acre, but the effect of increasing production is very obvious, after many tests, compared with the use of only erythromycin, the general increase in production of more than 10%. This enhancer, in combination with erythromycin, becomes an ideal plant growth regulator.
D.The enhancer of the plant growth regulator, erythromycin, is characterized by its composition and dosage as follows:
Magnesium sulfate: 4-8; Cobalt sulfate: 0. 5-1; Boric acid: 8-16; Copper sulfate: 0. 5-1; Manganese sulfate: 4-6; sodium molybdenum: 0. 5-1; Zinc sulfate: 4-6; myoside: 2-10.
And.The production method of the kind of erythromycin water agent is through the deep fermentation of erythromycin, fermentation acidification, plate frame pressure filtration, filter back silk, film concentration of several processes, its characteristics are:
1) Add an effective amount of protective agent and effective amount of emulsifier to the concentrate;
2), then adjust the pH of the concentrate.
Synthesis Method One
a.One used to synthesized-A preparation method for the preparation of bi-sterebie biotin, the raw material of biotin intermediates. The reaction steps are as follows:
1).In an ethanol magnesium acnossparmedly diethyl ester solution, add the sepsis salt and heat up to50～120C, insulation reaction4～15Hours;
2)Cool to room temperature, acid-adjustedpH＜3, the organic layer is divided, the water layer is extracted with aromatic sorsotic media, the organic layer is combined, and the3～5% of sodium bicarbonate water solution washorganic layer to neutral;
3)Then dry with desiccant, filter, recover aromatics from the filter after the aromatics solute light yellow liquid, add oil ether immersion, precipitated white solids after filtration.
4)With ethanol magnesium acnovicepreocyte diethyeest solution as a shrinking agent, the reaction condition is mild and the reaction is complete, it is dangerous, easy to operate, high yield, low cost and high purity advantages.
b.d-A synthetic method of biotin’s intermediate seilutin. The reaction steps are as follows:
1)Under the presence of organic acids and inorganic acids, terpenes bison biotin is used to relieve the pyrethroids;
2)Reaction, water dilution, decompression recovery of organic acids and water, extraction of acid water with organic solute;
3)Then use deionized water to wash the organic layer, reduce the pressure to recover the organic layer, light red oil-like viscose, and then add oil ether immersion, precipitate solidfiltration, that is, biplein biotin.
c.A preparation of intermediate hexahydropyrifal and[3，4-d]Miezole-2，4The method of diketon, which includes the following steps:
(1)Low temperature reaction, at low temperature, the thiosic acetic acid droplets are added to the non-proton solvent of alkali metal sulphide, with a temperature range of-5℃～-20Optional non-proton solventN，N-Dimethyl methamphetamine orN，N-The molar ratio of dimethyl acetylamide, alkali metal sulphide sofeto and thiosic acid is1∶0.1～1；
(2)High temperature reaction, after adding thio-daipyridine acid in the above steps, add hexhydrofurans and[3，4-d]Miezole-2，4-Diazepam and heatup quickly to80℃～130Between c, stirring reaction8～15Hours;
(3)To facilitate the analysis, the reaction ends, cools to room temperature, and stirs down to add a large amount of dilute acid to produce coarse, dilute acid as a non-proton solvent10～50times;
(4)Recrystallization, recrystallization of crude products pure, recrystallized solvents can be used methanol, ethanol, isopropyl alcohol or ethyl acetate.
D.Ad-The synthesis of biotin, including the following reaction processes:
1)The metapratotones-Shundipyrifac acid through estering reaction to generate external decyclone of single esters, split after the split to select the reduction of single ester base to obtain the desired absolute configuration of the internal ester;
2)Then replace oxygen with sulfur to get the sulfur ester, introduce the side chain through the gers react, and get(3aR，6aR)-1，3-DiazBase four hydrogen-1H-I’ve been told to do it.[3.4-d]Miezole-2-(3H)- ketone-Acrylic;
3)After hydrogenating the metalysin, the metaphobe biotin is then removed from the two ephenions, and then the pure, optically actived-Biotin;
4)Characterized by the use of concentrated sulfuric acid as a catalyst by
midazolam-Cedylonic acid and methanol esterification reaction for single
esterification, split with right amine, reduce single ester with boron
hydrogenated sodium, and produce thiopental estee with potassium ethyl sulfur.
Synthesis method 2
a.A method for producing d-biotin, including:
1)Culture of a coutegen and resistant to biotin metabolites and a microbiotin that produces d-biotin in a medium under aerobic conditions, as well as d-biotin strains derived from separation from fermentation fluids;
2)The preferred microorganisms are Kuttsy538-KA26, 538-17H4, 538-51F9,538-2A13 (DSMNo. 10609,10608,10610,10607);
b.Methods for the production of biotins from desulfurized biotin, including:
1)Contact desulfurized biotin with enzyme reaction systems containing BIOBs as well as NIFU and/or NIFS and isolate the resulting biotin from the reaction mixture;
2)Methods for the production of biotin from desulfurized biotin, including in a water-based medium, in the presence of desulfurized biotin, have been transformed by their own coded BIOB and NIFU and/or NIFS DNA sequences or in multiple plasmids contained in a single or independent forma, The biotin produced by separation from the medium.
c.Methods for the production of biotin from desulfurized biotin include contact with enzyme reaction systems containing BIOBs as well as NIFU and/or NIFS, and separation of the resulting biotin from the reaction mixture.
Seven, shedding acid
Extraction Method One
A method of extraction of natural lysare acid, including the following steps:
1The fermentation acid is filtered after the directed culture of the microorganism that can be fermented to produce the natural shedding acid.
2The leachant is absorbed with large hole adsorption resons with organic solvent seissing, the elution fluid is extracted after concentration, and the extract liquid is concentrated to obtain the crystallization rough;
3After dissolving the crystalline crude, absorb impurities with silicone, add hexane or benzene or petroleum ether or carbon tetrachloride crystalline additives, reduce pressure concentration, cool crystallization, washing, vacuum drying, making95More than % of natural shedding acid crystals.
Extraction Method 2
A method for the preparation of naturally active shedding acid, which contains the following steps:
1) Fungi that will be able to produce naturally active shedding acid are cultured in the first level liquid medium, and the fungus is selected from: grape spore mold genus, tail spore mold genus, quete mold genus, cymfordy genus, and genetically modified bacteria of the above-mentioned strains;
2Inoculated the above-mentioned cultured first-stage seed fluid on the second-stage liquid medium;
3The second-stage tank seed liquid obtained above will be inoculated in the third-stage liquid medium for a suitable period of time, and the fermentation of the third-stage liquid medium flow plus supplement will begin;
3Shedding acids collected from the above fermentation culture.
8, Geimoss ion fat
Preparation Method One
Fake monocytobacteria429The method of hydrolyzed beesque wax preparation of moss enestion is characterized by the following steps:
1), the production of active liquid esterase;429Residual, grease, sodium hydroxide, yeast paste, potassium dihydrophosphate, pseudomonas429At least the temperature is28Under the condition of c, press at least60r/minThe speed of stirring and fermentation at least22hour, so that itpH为7.1～7.6, add the defoamer, the ventilation of esterase vitality for900～1400U/LFermentation solution, in the fermentation solution to add flocculant centrifugal removal bacteria, obtain coarse enzyme solution, concentrate coarse enzyme solution,4500～600U/Lactive liquid esterase;
2), the production of beeswax dispersed emulsifier: in the beeswax to add emulsifier, so that it emulsified, access to beeswax dispersive emulsifier;
3), directional hydrolysis of ester bonds in beeswax: adding active liquid esterase to beeswax emulsifiers, to adjustpH7.1～7.3, stir, heat up to35～50At least directional hydrolysis at least3hour, hydrolysis near the end of the appropriate amount of extractor, so that beeswax hydrolysis;
4)The hydrolyzed beeswax is separated by resin and the moss ester product is produced.
Preparation Method 2
A soysterolB（stigmasterolAs the starting raw material, after a certain chemical reaction route, the synthesis series has a long-lasting target tote endothel synthesis method, characterized by:
1Extracted from soybeans, purified and chemicallyBSoybean sterols, synthesized by stereoscopic selective control, have2A3Alpha-based,22B23Beta epoxy has a passALong-acting moss enestion;
2Using the starting raw ingredient soysterolBSofaphinated synthetic compoundsC，CCompounds oxidized with metformin under alkaline conditionsD，DRe-open ring isomerization to get key intermediatesE，ESelective oxidation of control conditions2，3Bit double-key sizing sizing at the same time to getF，FTarget product with perethanizing trifluoroacetic acid to complete internal esterification and cycloxidation reaction at the same timeAAll synthesis requires only five steps of reaction to produce long-lasting moss endersubstances.
A preparation method for the growth regulator of a steroid plant, an endothelial ester, is a new type of plant growth regulator.
The use of pure plant alcoholcFor the starting raw material, after a certain chemical reaction route, short-step synthesis of taro moss blames the method of returning similars. Steps:
1From the oil industry raw materials after saponification extraction, purification to obtain chemicalCPlant self-alcohol.
2Plant self-alcohol with starting raw materialCThe wind vent of the synthetic compound by sulfonizing the compound is oxidized simultaneously by the metamethyl thagong cyclatoric well under alkaline conditionsE, the light on the ring gets off the middle manAUsed in polar solventsoBoEar-pressing yin oxidation can get the phoenix under the trifluoro-oxygen acid four-treated to get leap standard yieldYour, all synthetic routesThis- – Five-step reaction to get leap label productsB。
1Synergy reduction, containing metformin__０．１—９９％；
2One or more of the polynitols, mossesters, oleole, polysacium, alpha-ethyl acetate salt, or 6-aminoquine. 1—30%;
3One or more of direct-chain alkyl phenylates, lignin sulfonate, silicone, methylene cellulose sodium salts, energison osmosis agents, permeablebbs, polyvinyl alcohols, azon or tributylphosphates. 1-20%; clay, bentonite, talcum powder, diatomite, light calcium carbonate or one or more 0. 5—50%。
3The product can improve cotton production and quality, can control the length of cotton, reduce the cost of chemical control.
The preparation method of a rice bran active substance, twenty-eightanol and trianol, belongs to the comprehensive utilization of rice bran, especially rice bran wax.
1To crude wax as raw material, after the refining of coarse wax, the use of ultrasonic hydrolysated rice bran wax, the extraction of fatty alcohols, molecular distillation technology separation of twenty-eight anealcohol, trianol, the preparation of purity is greater than80% of the product.
2Using ultrasonic hydrolyzed rice bran wax and molecular distillation technology for the separation of twenty-eight analcoholls, trianol is a pioneering study, the establishment of the rice bran wax extraction of 28anol, trianol complete process, ultrasonic hydrolysis reaction than the general method shortened10hours more than, from12-16Hour reduction is reduced to1Within hours, the hydrolysis rate increases2times;
3Molecular distillation has been piloted to achieve the breakthrough of preparing high-purity bioactive substances 28anol and triamcinol. Product purity is high, iodine price is low, heavy metals and microbial content are in line with the requirements of food additives, for the future development and utilization of high carbon alcohol to create conditions.
Trianol is an effective biogrowth hormone.Simple purification method of preparing high purity of triavanol from natural resources such as beeswax,This method can make a high-purity triavanol CH with very low levels of twenty-eight anealcohols.3（ＣＨ2）28ＣＨ2ＯＨ．
In the previous person about extraction,Saping,After separation of the process,Added mixed solvent insulation crystallization method,Make the purity of the thirty-ananol in the95% or more,Among them, the content of twenty-eight anealcoholls is 0 to 2. 74%, with a yield of 0. 26 to 5%.
Ten, choline chloride
Synthesis Method One
Preparation process for highly stable choline chloride
1Made using the following weight ratio sins50% powdered choline chloride:70% of choline chloride liquid700-716, the fineness is60-120Purpose fine corn core meal300-350, the fineness is80-160Purpose diatom soil120-150，
2Made using the following weight ratio sins60% powdered choline chloride:70% of choline chloride liquid850-865, the fineness is60-120Purpose corn core meal350-400, the fineness is80-160Purpose diatom soil powder50-80，
3) After mixing the above weight sins than the components, the200-350Dry to water content at s.C.2% is made.
Synthesis method 2
a.The method of making choline chloride is made from hydrochloric acid, trimethamide and epoxyethylene as raw material. Ethylene oxide used is an intermediate product that uses ethylene-catalyzed oxidation, catalytic direct hydration to produce ethylene glycol – containing trace amounts of ethylene glycol (heavyThe ethylene oxide aqueous solution, the ethylene oxide aqueous solution before entering the reaction system, the first evaporation separation removes the contained ethylene glycol, in the form of ethane oxide steam accompanied by water vapor into the reactor. According to the invention to manufacture choline chloride, can improve the safety of the reaction, at the same time the quality of the product is also very good.
b.The manufacturing method of choline chloride,
1)By hydrochloric acid and trimethylamine to 1: (1 to 1. 01) (Mole) ratio, at a temperature of 30 to 40 degrees C to carry out a salt reaction, the formation of trimethylamine hydrochloride,
2)Then with ethylene oxide to 1:1. 05 (mole) ratio, at a temperature of 30 to 70 degrees C to add the reaction, the manufacture of choline chloride, its characteristics are the use of ethylene oxide containing 8 (weight) % of ethylene oxide and 0. 3 to 4. 5 (by ethyl) % glycol water solution,
3)Before entering the reaction system, the ethylene oxide solution uses the boiling difference between ethylene oxide and ethylene glycol, and after the first evaporation separation is removed, it enters the reactor in the form of ethylene oxide vapor accompanied by water vapor.
Synthesis method 2
Synthesis of a choline chloride
1)Synthesis at normal temperature or low pressure with trimethylamine and chloroethanol as raw material and alkali as catalyst;
2)It is characterized by a molar ratio of 1. 0:0. 9 to 1. 1, the catalyst is choline salt;
3)The catalyst addition is 0. 1-10%, reaction temperature of 20-150 degrees C, reaction in the agitator for 2-5 hours, conversion rate of 99%.
A plant growth regulator, mainly by nucleotides0.01～15% Choline chloride1～60% emulsifier1～15% and water composition.
1)High efficiency, non-toxic, strong internal suction;
2)Mainly used in lychee, dragon’s eye, citrus and other fruit trees and melon vegetables, with enhanced photosynthesis, reduce falling fruit, improve the yield of fruit, enhance resistance, so that fruit coloring bright, improve product quality and other good role.
Combined in Method One
Methods for the preparation of inositolfrom plant materials, which include the following steps:
(a)Under the condition of not promoting complete hydrolysis into inositol, the water-containing slurry of plant materials is treated with inositol hexaphosphatase to delysify at least one part of inositol hexaphosphate, inositol hexaphosphate and inositol hexaphosphate magnesium into inositol phosphoric acid;
(b)The slurry is separated into water-soluble grade and water insoluble grade;
(c)the water-soluble fractions are separated into the first ion grade and the first other fractions containing the anion component containing inositol phosphoric acid;
(D)Hydrolysis of inositol phosphoric acid in the first ion grade;
I think it is aThe hydrolytic first ion fractions were separated into the second ion level and the second neutral fraction containing inositol.
Synthesis method 2
A new method for extracting inositol, especially a new method of extracting inositol from fitin hydrolyses or phytic acid hydrolyses, is that after the phytosion of fitin hydrolysis over yang ionic resin, the liquid concentrate is concentrated or phytic acid hydrolysis concentrate is concentrated, and then the phosphoric acid in the concentrate is removed by low-grade alcohol, and pure inositol is obtained. This method does not need to treat fitin hydrolysis or phytic acid hydrolysis with an ionic resin, which fundamentally solves the problem of the difficulty of anion resin regeneration, simplifies the production process and reduces the production cost.
Synthesis method three
Using glucose as raw material, put into the reactor, add ethanol and boric acid complex, into the reactor with sodium nitrite and ice acetic acid oxidation, circulation and ring treatment, hydrolysis and, add copper sulfate precipitation acidification and integration, filtered into the crystallization kettle concentrated crystallization, distilled water to remove the clutter, decolorization after secondary crystallization, dehydration separation and drying crushing. The use of glucose as the main raw material, low cost, high yield of inositol, low production costs, investment, no pollution, ethanol in production, mother liquor recovery and reuse, advanced production technology, safety, product quality stability.
Synthesis Method FOUR
A low-pressure catalytic hydrolysis method for the production of inositol, characterized by the following steps:
A. Dip: the dry food fitin added to the water purification even mixing, the ratio is (weight ratio) fitin: water: 1:4-1:6, heating to 30 degrees C to 50 degrees C, soaked 1 -2 hours, the formation of fitin suspension;
B. A catalyst slurry treatment is added to the above fitin suspension 0. 5-1 hours, ratio (weight ratio): catalyst: dry fittin s 1:40-1:60.
C. The above-mentioned slurry generator is added to the reactor for catalytic hydrolysis reaction, the temperature is: 160 degrees C – 185 degrees C, the pressure is: 0. 7-1Mpa, time 3-6 hours;
D. The producing inositol is collected from the reaction mixture.
Synthesis method five,
A kind of rice bran(Bran)Methods for extracting inositol, including the following steps:
(1) Put rice bran into the load1％-2% concentration of acid-soaked solution soaked in the acid immersion pool, reaction2-3Hours. Hydrochloric acid verssa ratio6～7∶1；
(2) After the reaction is completed, the impurities are removed by filtration, the mother solution is then placed in the reactor, and then the content is added to15％-20% of sodium hydroxide solution, regulatedPHValue is11-13；
(3) Then by the plate frame filter filter, filter cake10-15Times of water dissolves, heats up to boiling, and then separates by centrifugal,That is, dry coarse plantmates;
(4) In the pressurized stirring hydrolysate, add the dry coarse plantacids made by the above method, solid/The liquid ratio is1∶15-25, add the water and heat up under stirring until150-160The pressure is0.5-1, Muppa, hydrolysis at this temperature pressure11-16Hours;
(5) Press the hydrolycated solution into the medium and kettle, i.e.25％-30% concentration of calcium hydroxide solution in-sum toPH为8.5-9。 It is characterized by:
(6) After the above step (5), the fluid after the water is filtered and pressed into the decolorization tank immediately addthe amount of liquid0.6％～1.0% of activated charcoal, boiled1～2hours, for initial decolorization, in the initial decolorization of the hydrolysis intoCO2to make the hydrolysisPHValue reached6～7After filtration, let the hydrolysis into the yang, anion exchange column, cation exchange resin with sulfonate type or argon acid type, anion exchange resin with buramine to thamines or seasonamine type, and then use the amount of resin3-4Double distilled water to wash ion exchange column, combine hydrolysis and water ingresss, and concentrate it with an open concentrator to the relative density of the liquid1.10～1.17To move the concentrate to a decolorizing pot and add the concentrate to the0.8％～1.2% of activated charcoal, boiled15～20Minutes discolor, then filter with a sand rod to the cooling pan, when cooled to32℃±2At c, the dehydrator is fed to remove the female fluid, which is crystallized with the equivalent of inositol0.2～0.3times the medicinal alcohol rinses once, placed in50°～80Dry in a drying box.
Synthesis Method One
A method of niacin production characterized by
1)First put the catalyst in the400-450Air activation at sC6-8Hour to use, to3-Methylmethamphetamine is the raw material, after the vaporizer in the180-200Vaporization at the temperature of c, pressed with air and water vapor0．002∶0．33∶0．06Volume ratio mixing, into a column tube reactor filled with activated catalysts, in the300-350Under the condition of oxidation, the reactor is connected with the molten salt tank, the heating reaction or carries the heat released by the reaction, generates the high temperature reaction gas through the heat exchanger, enters the pounce collector, and condenses the powdery crude products of niacin, the exhaust gas enters the water washing tower, the trace niacin is absorbed, discharged by the upper part of the water wash tower.
2)The crude product obtained by the pouncer is pressed by the coarse product of niacin: water: the active carbon weight ratio is1∶4-6∶0．05-0．08Place in the reactor and heat to85-95Water release color, thermal filtration, filter into the cooling pool crystal, the filter cooled to room temperature, centrifugation drying, water content15-20% of niacin, then dried, that is, niacin.
Synthesis method 2
The direct gas phase oxidation of beta-methylpyridine to improve the preparation of niacin. The water and beta-methylmethium are fed into the catalyst bed separately, and the catalyst is based on the titanium dioxide carrier, which is prepared by sulfate method, which has a high surface area and 5-50% of the content of zirconia.
Preparation Method One
The method of producing glycine, characterized by the action of microbial enzyme, enables the hydrolysis reaction solution of glycosion in the hydrolysis reaction system, thus transforming glycosirides into glycine, accompanied by the production of ammonia, in which the hydrolysis reaction system contains at least one organic impurity compound that inhibits the microbial enzyme, the organic impurity compound has a molecular weight.95and contains at least one member of the structure of the selected argon, pyridine, amide, amino, hydroxyl and subpropyl amine, the hydrolysis reaction is performed under such conditions, where the content of organic impurity compounds inhibited by microbial enzymes in the hydrolysis reaction system is maintained during the hydrolysis reaction10Weight % or less, based on the weight of the hydrolysis reaction system.
Preparation Method 2
A method for preparing glycine, which includes the following steps:
1)The mixture of hydroxyethyl solution or the mixture that produces hydroxyethyl is mixed with ammonia compounds to obtain ammonia reaction fluid;
2)The above ammonia reaction fluid is mixed with inorganic acid to obtain acid solution;
3)The above-mentioned acid solution is combined with lime milk and is to be moderated;
3)After treatment of the above-mentioned medium-sum liquid, get glycine.
A method of purified the crude glycine in the production process, which consists of two steps:
1)Use 50-80% of alcohol aqueous solution wash edgygin, glycine fine,
2)Steps1)Washing master liquid inIElectrodialysis desalting treatment, to remove ammonium chloride mother liquidIITo be used in a circulating solution of alcohol before washing,
4)The steps will be taken2)Strong water obtained after electrodialysis desalting treatmentIIConcentrated, ammonium chloride crystals, concentrated concentrated waterIAdd the circulating sleeve in the electrodialisive fraction.
Production Method One
From1One deoxygenation.D。 Su-I-ketone sugar (DTP) and4One hydroxy oneLA sulpnine (HTProduction of vitaminsB6this method, which includes makingDTP和HTWith the ability byDTP和HTSynthetic vitaminsB6The enzyme reaction system prepared by the microbial cells is in contact, and the dinucleic acid phosphoric acid is chanted in the pyridoxamine glands (NADp”), pyridoxilamine gland son – nucleochlor acid (Over() and glandular risotto-scented triphosphate ()ATPThe contact in question occurs in the presence of the present.
Production Method 2
A method of producing vitamin B6 includes the cultivation of microorganisms belonging to the genus root tumor bacteria that can produce vitamin B6 in the medium under aerobic conditions, and then isolated from the culture. The culture is necessary for microbial growth of absorbable carbon sources, digestable nitrogen, inorganic salts and other nutrients, the medium culture can also contain acetone acid, D-glycosine, ethanolaldehyde, glycine, 1-deoxy-D-su-su-su-ketone sugar, 4-hydroxy-L-sucnine or its mixture.