Vaccines are known to be stored in cold storage and are generally safe at 2 to 8 degrees Celsius. At other temperatures, the proteins contained in vaccines break down, causing them to become inactivated and millions of children around the world to miss out on vaccinations, but this is now expected to be a thing of the past.
British scientists have cleverly coated proteins in silicon dioxide, allowing the structure of vaccines to remain intact even when heated to 100 degrees Celsius or kept at room temperature for up to three years.
The university of Bath, in collaboration with Newcastle University, developed the ‘silicification’ technique, and the research is published in the latest issue of scientific Reports.
In the latest study, two doses of tetanus vaccine were sent by ordinary post from the University of Bath to Newcastle University (300 miles away, it would take a day or two to get there).
A vaccine “dressed up in silica”;
The other was unprotected.
The non-toxic material silicon dioxide is the main component of sand.
The results showed that the “silicification” vaccine successfully triggered the immune response in mice, indicating that the vaccine was active.
The unprotected vaccine did not trigger an immune response, indicating that the vaccine had been damaged during transport.
“The results are exciting,” said Dr Essel Satabawa, from the University of Bath’s Department of Chemistry, who led the latest research. “This new technique not only protects the protein structure of the vaccine, but also retains its function – immunogenicity.”
“Our current focus is on tetanus vaccine, which is part of the DTP vaccine (diphtheria, tetanus and pertussis) that children receive,” Satabawa explains.
Next, we will work on thermally stable diphtheria and pertussis vaccines.
Ultimately, we want to ‘silicify’ the entire DTP triple vaccine so that every child can get the DTP vaccine without having to rely on cold chain transportation.”
, Barbara, she said “silicide” vaccine for humans within 5 to 15 years, she hopes this kind of “silicide” technique was used to store and transport all childhood vaccines and antibody and enzyme and other protein products, “our aim is to use the thermal stability and reduce dependence on cold chain, the eradication of vaccine preventable diseases in low-income countries.”
It has been reported that up to 50 per cent of vaccines are discarded before use due to exposure to suboptimal temperatures.
According to the World Health Organization, 19.4 million babies were not routinely vaccinated in 2018.